Penicillin Production in an Inverse Fluidized Bed Bioreactor
نویسندگان
چکیده
The inverse fluidized bed bioreactor was adapted for the axenic culture of heterotrophic microorganisms. Penicillin V synthesized by Penicillium chrysogenum ATCC 28089 was used as a model system for secondary metabolite production. The biomass growth rate was controlled by the rate of nutrient addition while an eroder in the inner draft tube limited the maximum biofilm thickness. When a lactose-rich, mineral salts medium was added at a rate of 0.024 l .h -I , the maximum specific productivity was 5.79 × | 0 4 g (Pen V). g ( b i o m a s s ) l . h 1.
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